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Jaya Preethi, P.
- Synthesis, Characterization and Biological Activity of Coumarin Derivatives
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1 Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, IN
Source
Research Journal of Science and Technology, Vol 4, No 6 (2012), Pagination: 252-257Abstract
The coumarin-3-carboxylate prepared by known Knovengeal condensation. The coumarin-3-carbohydrazide prepared by reaction between formed carboxylate derivative with Hydrazine hydrate. The condensation of coumarin-3-carbohydrazide (CD-3) with phenylisothiocynate gives coumarin-3-carbo-N-phenylthiosemicarbazide (CD-4). The cyclization of CD-4 under different reaction conditions gives 1, 3, 4-oxadiazole, 1,3,4- thiadiazole, 1,2,4-triazole, thiazolidinone and thiopyrimidone. The synthesized compounds were charectarized by spectral analysis (IR, 1HNMR, Mass). All the compounds were screened for their Antiinflammatory, Analgesic and Antituberculosis activity. The disc diffusion method was used for Antituberculosis activity. The MIC was determined by the micro broth dilution method using Mueller-Hinton broth. The Analgesic activity was performed by Acetic acid induced method. The Antiinflammatory activity was performed by Carrageenan induced paw edema method.Keywords
Knovengeal Condensation, Phenylisothiocynate, Characterization, Anti Tuberculosis Activity.- Evaluation of Anti-Anxiety Activity of Alcoholic Extract of Cyndon dactylon Linn. in Experimental Animal Models
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Authors
Affiliations
1 Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode, Tamil Nadu, 638052, IN
1 Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode, Tamil Nadu, 638052, IN